Cooperation through the regional organisations has become one of the key mechanisms in strengthening resilience and global cooperation in the cyber domain. The Latin-American and Caribbean region (LAC), for instance, has made significant progress in its digital transformation and significantly reduced its vulnerabilities to digital risks thanks to a comprehensive approach promoted through the regional actors, such as the Organisation of American States. Yet, only the largest and wealthiest countries in the region have institutions dedicated to cybersecurity. In the Asia-Pacific region, the institutional landscape is more diverse with organisations such as the Association of South-East Asian Nations (ASEAN), the ASEAN Regional Forum (ARF), the Asia-Pacific Economic Cooperation (APEC), the East Asia Summit (EAS), and the Shanghai Cooperation Organisation (SCO) providing an important contribution to the global debates. Appreciating the value of working together through the regional organisations, the EU is actively working with these organisations towards strengthening resilience of the global cyber-ecosystem.